Impaired spatial learning in the APPSwe�+�PSEN1?E9 bigenic mouse model of Alzheimer?s disease
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Perfusion and vascular response as early markers in a bigenic mouse model of Alzheimer’s Disease
Purpose An accumulating body of evidence suggests a causative link between cerebrovascular dysfunction and Alzheimer’s disease (AD) (1,2). Over recent years, arterial spin labeling (ASL) MRI has, like other perfusion imaging modalities, demonstrated brain hypoperfusion a long time before the onset of dementia (3,4). Although several transgenic AD models are available, only a limited amount of r...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2007
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2006.00221.x